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Home » Now Know All about Polydactyly: Cause, Symptoms, Diagnosis, Treatment
Child CareHealth Problems

Now Know All about Polydactyly: Cause, Symptoms, Diagnosis, Treatment

Staff
Last updated: September 23, 2024 6:47 am
By Staff
8 Min Read
Now Know All about Birth Defect Polydactyly

Polydactyly is a congenital condition where a person is born with extra fingers or toes. This common birth defect, which affects both hands and feet, can manifest as a small, non-functional digit or a fully developed finger or toe. The extra digit is typically located next to the pinky finger or toe, though it can sometimes appear beside the thumb or big toe. Polydactyly is present at birth and may occur as an isolated condition or as part of a genetic syndrome. It affects about 1 in 500 to 1 in 1,000 live births.

Contents
What is Polydactyly?How is Polydactyly Caused?History and Science of PolydactylyRisk Factors for PolydactylyTreatment for PolydactylyCan Polydactyly Be Prevented?Is Polydactyly Hereditary?Can Polydactyly Be Cured?Conclusion

What is Polydactyly?

Polydactyly, also known as hyperdactyly, refers to the presence of more than five fingers or toes on one or both hands or feet. It is classified into three main types:

  1. Preaxial polydactyly: The extra digit is located on the thumb side (radial side) or big toe.
  2. Postaxial polydactyly: The extra digit appears on the pinky side (ulnar side) of the hand or foot. This is the most common type.
  3. Central polydactyly: The extra digit is located between the other fingers or toes.

Polydactyly can occur in either a simple form (where the extra digit is underdeveloped or a small nub) or a complex form (where the digit is fully developed with bones, tendons, and nerves).

Also, read: Now Know All about Hypospadias: Cause, Symptoms, Diagnosis, Treatment

How is Polydactyly Caused?

It occurs due to a genetic mutation that affects the development of the hands or feet while the fetus is forming in the womb. In early pregnancy, the development of the fingers and toes involves the formation of small limb buds, which later separated into distinct digits. A mutation in certain genes disrupts this process, causing an extra digit to form.

Key factors involved in the development of polydactyly include:

  • Gene mutations: Mutations in specific genes like GLI3 and SHH (Sonic Hedgehog) can lead to polydactyly. These genes regulate the patterning of digits during embryonic development.
  • Syndromic polydactyly: In some cases, polydactyly is part of a larger genetic syndrome, such as Ellis-van Creveld syndrome, Greig cephalopolysyndactyly syndrome, or Bardet-Biedl syndrome, which also cause other physical anomalies.

History and Science of Polydactyly

It has been recognized throughout history, and there are records of the condition in ancient cultures. Archaeological evidence shows that people born with extra digits were often depicted in prehistoric art, with examples found in ancient Egypt and Mesoamerican cultures. The first scientific descriptions of polydactyly can be traced to early medical texts, with the condition being understood in more detail as genetics and embryology advanced in the 20th century.

In recent years, research into the genetic mechanisms behind polydactyly has identified several critical signaling pathways that influence limb development. The Sonic Hedgehog (SHH) signaling pathway, for example, plays a major role in the formation of digits. Disruptions in this pathway can result in polydactyly, syndactyly (webbed fingers or toes), or other limb malformations.

Risk Factors for Polydactyly

Several factors can increase the likelihood of a child being born with polydactyly:

  1. Genetics: A family history of it significantly increases the risk. The condition can be passed down in an autosomal dominant inheritance pattern, meaning only one parent needs to carry the gene mutation for the child to inherit it.
  2. Ethnicity: It is more common in certain ethnic groups. For example, it is more frequent among African Americans than in other populations.
  3. Syndromes: Certain genetic syndromes, as mentioned earlier, include polydactyly as part of a broader set of birth defects.
  4. Environmental factors: Although less well understood, some environmental factors during pregnancy, such as drug or alcohol use, could play a role in increasing the risk of polydactyly.

Treatment for Polydactyly

The treatment for it depends on the type and severity of the condition. In some cases, if the extra digit is small and non-functional, treatment may not be necessary. However, if the extra digit is large or affects hand or foot function, surgical removal is the standard approach.

  1. Surgical removal: In most cases, surgery is performed during infancy or early childhood to remove the extra digit and ensure normal hand or foot function. Surgery can involve:
    • Removing the extra digit, especially if it is fully formed and attached by bones, tendons, and nerves.
    • Repairing or reconstructing the area where the extra digit was removed to improve the appearance and function.
  2. Postoperative care: After surgery, the child may need a cast or splint to protect the surgical site. Physical therapy may also be recommended to ensure normal hand or foot movement.

Can Polydactyly Be Prevented?

There is no known way to prevent it, as it is primarily a genetic condition. However, genetic counseling may be helpful for parents who have a family history of the condition or other congenital anomalies. Early prenatal screenings can detect polydactyly during pregnancy, allowing for early medical consultation and planning for treatment if necessary.

Is Polydactyly Hereditary?

Yes, it is often hereditary. It is commonly passed down through autosomal dominant inheritance, meaning that if one parent has polydactyly, there is a 50% chance of passing it on to their child. In some cases, polydactyly may occur as a spontaneous genetic mutation without a family history.

Can Polydactyly Be Cured?

It can be surgically corrected, especially in cases where the extra digit interferes with normal function or causes aesthetic concerns. The surgery is typically successful in restoring normal hand or foot function, and most children recover fully with little or no complications.

In most cases, the removal of the extra digit provides a functional cure, and the individual can lead a normal life without long-term effects from the condition.

Conclusion

It is a common congenital condition where a person is born with extra fingers or toes. It is caused by genetic mutations affecting the development of the limbs during fetal growth. While the condition can be hereditary, it can also occur spontaneously. Surgical treatment is typically effective in removing the extra digit and restoring normal function. While there is no way to prevent polydactyly, genetic counseling, and early diagnosis can help families prepare for treatment and care.

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